New Mangosteen Research Establishes Xanthone Measurement Standard, Points to Whole Fruit Usage for Greater Absorption

More Xanthone research and science revealed :

 

Preliminary
research on XanGo(R) Juice shows proprietary
whole fruit formula leads
to high xanthone absorption

 

LEHI, Utah, June 22
/PRNewswire/ -- XanGo,
LLC, recognized creator of the mangosteen
supplement category is
leading scientific exploration of the whole
mangosteen fruit (Garcinia
mangostana) through a tiered approach based
on safety, standardization
and efficacy. In a study published in the
June 2007 issue of the
Journal of Separation Science, researchers
established a credible
scientific method for testing and measuring
xanthones. Preliminary
results from a separate study conducted on
XanGo® Juice,
indicate usage of the whole mangosteen fruit
as a delivery vehicle
leads to high xanthone absorption.

"These two studies put into
context how to
measure xanthones and how to effectively
absorb these phytonutrients,"
said Edward Walker, Ph.D., of Weber State
University, lead researcher
on the published study. "A xanthone
measurement standard is in place.
Now claims concerning xanthone quantity and
efficacy can be evaluated
through credible research."

Published study sets
xanthone measurement
standard

In the peer-reviewed method
for quantifying
xanthones from the mangosteen fruit, Walker
used the high performance
liquid chromatography (HPLC) analysis to
create an analytical method
that accurately identifies xanthones from the
rind of the mangosteen
fruit.

According to Walker, an
80:20 acetone/water
mixture was used to extract the xanthones
from dried, ground whole
mangosteen fruit rind.

"A total of six xanthones
were purified by
preparative HPLC, utilizing the same solvent
system and UV detection as
for the analytical method," said Walker.
"Each compound has unique UV
absorption spectra that allows for easy
identification of the xanthone
found naturally in the mangosteen fruit."

Research lab ChromaDex
developed the
standards, and in accordance with AOAC
protocol, performed a single lab
validation to quantify xanthones through
comparison measurement of
detector response factors of individual
xanthones. Walker said the
research team chose the whole mangosteen
fruit rind as the starting
point because it holds the highest
concentration of xanthones in their
natural, unaltered state.

"Although researchers are in
the process of
identifying and measuring additional
xanthones, this study, published
in the Journal of Separation Science, ensures
a more consistent and
reliable marketing of mangosteen products to
consumers relative to
claims of xanthone content," said Walker.

Whole fruit drives
absorption

A pre-clinical, preliminary
28-day study of
XanGo Juice by Charles River Laboratories
Montreal identified the
bioavailability of xanthones to determine how
many xanthones are
actually absorbed and the pathway they
travel. Study director Susan
McPherson, MSc, senior research scientist at
Charles River
Laboratories, said preliminary research
findings demonstrate that the
proprietary whole fruit formula in XanGo
Juice leads to high levels of
xanthone absorption.

Ongoing research shows high
absorption of
xanthones in defined dosages, with elements
of the whole mangosteen
fruit as a delivery vehicle. Unnaturally
elevated levels of xanthone
consumption actually were shown to result in
decreased absorption
efficiency.

Preliminary results also
showed long-term
daily consumption of XanGo Juice to increase
levels of xanthones in the
blood.

"This is an issue of quality
over quantity,"
said Mike Pugh, manager, research and
development at XanGo. "These
preliminary findings add further context to
the published xanthone
measurement study. Ongoing research shows
artificially inflating or
manipulating a product with xanthone extracts
may not add any value.
The mangosteen presents more value in its
whole fruit form, as
presented in XanGo Juice. There are many
other phytochemicals found in
the fruit that have beneficial effects which
are lost in extraction or
jeopardized when the natural balance of the
fruit is manipulated."

XanGo Juice is produced
through a
proprietary whole fruit formula based on a
puree of the entire
mangosteen.

The whole mangosteen fruit
contains 39
different xanthones. The rind of the
mangosteen is considered nature's
most abundant source of xanthones. Xanthones,
a unique class of
phytonutrients, possess a range of powerful
antioxidant properties.

To learn more about research
and exploration
of the whole fruit mangosteen, visit: http://www.thewholefruit.com.

About XANGO

XANGO, LLC is a recognized
category creator
as the first company to market a premium
mangosteen beverage,
XANGO® Juice, to consumers worldwide.
XANGO continues to lead
the category we created by driving the
development and success of
functional mangosteen products. Based in
Utah, XANGO is privately-owned
and powered by a global network of
independent distributors. XANGO's
expansive operations include the U.S. and
numerous international
markets such as Canada, Mexico, Japan,
Germany and Malaysia.

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